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OX-BILE EXTRACT POWDER

GENERAL INFORMATION:

Titan Biotech Ltd. has prepared Bile Extract Powder (Ox Bile Desiccated), dried or desiccated which contains ox bile acids. This powder is specifically been developed for Pharmaceutical Industry, which is prepared by a low temperature dehydration process which ensures a uniform product. Bile Extract Powder, dried is a mixture of conjugated bile acids (Cholic Acid, Deoxycholic Acid, Taurocholic and Glycocholic Acids). It is a straight forward drying of Ox Bile liquid, which contains all of the constituents characteristics, found in Ox Bile. None of the bile salts, bile pigments cholesterol, mucin, etc. has been removed.

It is excreted by the liver and stored in the Gallbladder until needed to assist in digestion of lipids or fats. Bile salts, which are the active components of the Bile Extract Powder, assist in breaking down cholesterol and other fat components in the intestines. Bile Extract Powder supplement helps emulsify fats and promotes absorption of fat-soluble vitamins such as Vitamins K, A, D and E.                          

Bile Extract Powder is used to emulsify lipids in food passing through the intestine to enable fat digestion and absorption through the intestinal wall.  Bile salts aid in the breakdown of saturated fats that the digestive system has not been able to convert into unsaturated fats.  The body uses these unsaturated fats to manufacture Essential Vitamins and Hormones. Many individuals without proper Gallbladder function find it helpful to supplement with the best Bile Salts. 

A deficiency of bile production or decreased excretion of bile by the Gallbladder can lead to Gallstones. These Gallstones are formed from various combinations of cholesterol, concentrated bile, minerals and pigments.

FUNCTIONS OF BILE EXTRACT POWDER (OX BILE DESICCATED):

·       Contributing to cholesterol metabolism by promoting the excretion   of cholesterol.

·       Hepatic synthesis of bile acids is the primary pathway for cholesterol catabolism.

·       Bile acids play a crucial role in dietary lipid digestion and absorption, and also act as versatile signaling molecules 

·     Bile-acid-mediated activation of FXR-α- signaling pathways regulate the Enterohepatic Recycling of bile acids, protect against their accumulation in the liver and inhibit their own biosynthesis.

·   It controls immune function, liver and Gallbladder physiology, glucose & energy homeostasis.

·      Denaturing dietary proteins, thereby accelerating their breakdown by pancreatic proteases.

·    Having direct and indirect antimicrobial effects. In this capacity, recent evidence suggests bile acids are mediators of high-fat diet-induced changes in the gut microbiota.

·         Acting as signaling molecules outside of the gastrointestinal tract, thereby representing another mechanism by which the gut microbiota influences the metabolism of the host.

 BENEFITS OF BILE EXTRACT POWDER (OX BILE DESICCATED):

·         It emulsifies fat soluble Vitamins (A, D, K & E) which improve their absorption.

·         It removes excess cholesterol and fat.

·         It helps in preventing Gallstones or Choledochal Cysts.

·         It helps in treating many severe liver diseases like Cirrhosis and Hepatitis.

·         It also helps in treating small intestine diseases like Crohn's Disease. 

·         It helps in moderating cholesterol and triglycerides.

·         It controls the Heartburn or Gastroesophageal Reflux Disease (GERD).

·         It helps in keeping the small intestines free from micro-organisms.

·         It plays an important role in making the stool soft by promoting the addition of water into the stool

·         It serves as a carries of toxins.  The liver filters the toxins and dumps them into the bile.  Bile then carries the toxins to the intestines where they are absorbed by dietary fiber and excreted.

STANDARD SPECIFICATION:

PHYSICAL PARAMETERS

SL.NO.

PRODUCT PARAMETERS

SPECIFICATION

1.

Appearance

Greenish to yellowish colour free flowing powder.

2.

Solubility (2% soln. at 25°C) Soluble in distilled water and alcohol.

CHEMICAL PARAMETERS

SL.NO.

PRODUCT PARAMETERS

SPECIFICATION

1.

pH (2% soln. at 25oC)

6.0 - 7.0

2.

Loss on drying (at 105 ºC)

NMT- 5.0%

3.

Cholic Acid

NLT - 45.0%

4.

Total Ash              NMT- 20.0%

 

MICROBIAL PARAMETERS

SL.NO.

PRODUCT PARAMETERS

SPECIFICATION

1.

Total Viable Count

NMT- 10,000cfu/gm

2.

Escherichia coli

Negative

3.

Salmonella spp.

Negative

4.

Yeast & molds                100cfu/gm

USES OF BILE EXTRACT POWDER (OX BILE DESICCATED):

Bile Extract Powder (Ox Bile Desiccated) can be used to in the following      indications:

Fat Breakdown and Vitamin Absorption-

One of the primary ways it can be used is to assist the body in the breaking down of fats and the assimilation of vitamins A, D, E, and K. With the intake of Bile Extract Powder with food it offers better digestion of some of the more complex nutrients and minerals, which in turn contributes to better health. In the absence of bile, food can still be digested, but a lot of the nutritive value is lost or flushed out before it can be useful.

Constipation Relief-

Bile disruption also affects intestinal motility and absorption of nutrients in the colon. People who aren’t able to properly pull fats and vitamins out of their food during digestion often end up with constipation and bowel obstructions since the intestines and colon usually depend on fatty oils to process stools. When these are missing or inadequate, the result is often a dense mass that is difficult if not impossible to pass. With the intake of Bile Extract Powder in these cases, promotes digestive health, which can cure the root cause of the constipation.

Gallstone Prevention-

The liver stores bile in a small sac called the Gallbladder, from which it is distributed to the body. A lack of bile or a production imbalance may lead to wide swings in cholesterol and fat levels in the bloodstream. This is a contributing factor in the formation of Gallstones, or calcified obstructions of the Gallbladder. People who are prone to this condition by in taking of Bile Extract Powder helps in restoring proper liver functionality and preventing painful stones.

 

Treatment of Liver Diseases-

The supplement might also help treat certain liver diseases, particularly Cirrhosis. Cirrhosis happens when the liver’s tissues stop regenerating and begin turning to thick scar tissue. This impedes the liver’s ability to do much of anything, including bile regulation. Supplementing with Bile Extract Powder helps patients overcome from the disease’s side effects.

EFFICACY:

Bile is a substance excreted by the livers of mammals to assist in the chemical breakdown of fats and the absorption of certain vitamins in the digestive process. The Bile Extract Powder resembles the bile which is produced in our bodies naturally in its chemical structure. That is why it has been successfully proven to replicate and augment the production of bile in the human liver for faster and better food breakdown and nutrient absorption. 

The Bile Extract Powder offers speed recovery in patient who has undergone a Cholecystectomy, which is the surgical removal of the Gallbladder by offering proper digestion and complete nutrient absorption in order to stay healthy.

 

CONTRAINDICATION & CAUTIONS:

Do not use Bile Extract Powder (Ox Bile Desiccated) in case of hypersensitivity or allergy.

The application of Bile Extract Powder (Ox Bile Desiccated) in newborn children is not safe.

During pregnancy women are recommended to consult their health care provider prior to taking Bile Extract Powder (Ox Bile Desiccated).

RECOMMENDED DOSAGES:        

Medicinal Specialists/Formulators may design Bile Extract Powder (Ox Bile Desiccated) Supplement as per their formulations.

SIDE EFFECTS:

In rare cases it can cause: nausea, diarrhea, upset stomach and headache.

 

Std. Packing   :  25 Kg, HDPE Drum.

Best Before     :  36 Months

Storage           :  Hygroscopic by nature, store the material below 25ºC, protect from direct sunlight.           

 

 
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